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This year’s American Association for Cancer Research (AACR) annual meeting took place on 1–5 April in Washington, DC, USA. The program committee Chair was Kornelia Polyak, MD, PhD, from the Dana-Farber Cancer Institute, Boston, Massachusetts.
On Monday 3rd April, a poster (1701 / 20) by Eugenio Gaudio, from the Institute of Oncology Research, Bellinzona, Switzerland, et al. titled “The novel anti-CD205 antibody drug conjugate (ADC) MEN1309 shows strong anti-tumoral activity in Diffuse Large B-Cell Lymphoma (DLBCL)” was presented.
The group exposed MEN1309 and IgG-conjugated DM4 (control) to 24 DLBCL cell lines for 72 hours. Xenografts (15 x 106 cells/mouse, 200μL of PBS) were established subcutaneously in female NOD-SCID mice; IV treatment started when tumors reached a volume of 250–350mm3.
The poster concluded by stating that the novel ADC MEN1309 had strong in vitro and in vivo anti-tumor activity in DLBCL models, which is highly correlated with the expression of its target.
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