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On Monday 3rd April during this year’s American Association for Cancer Research (AACR) annual meeting, a poster (2033 / 5) by Adam D. Curtis, from the Eastern Maine Medical Center, Brewer, ME, et al. titled “Testing the combined effects of low dose olaparib plus ibrutinib on MCL cytotoxicity” was presented.
The group aimed to potentially improve ibrutinib therapy for MCL by combining it with olaparib, a DNA damage response inhibitor, and testing the combination in MCL cells in vitro.
The poster was concluded by hypothesizing that ibrutinib combined with olaparib potentially could improve response rate and duration in patients with MCL, as well as reducing adverse events.
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