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On Monday 3rd April at this year’s American Association for Cancer Research (AACR) annual meeting, a poster (2651 / 10) by Eugenio Gaudio, from the Institute of Oncology Research, Bellinzona, Switzerland, et al. titled “A novel CD19 targeting antibody-drug conjugate, huB4-DGN462, shows promising in vitro and in vivo activity in CD19-positive lymphoma models” was presented.
The group investigated the preclinical activity of a novel CD19-specifc ADC, consisting of the humanized anti-CD19 antibody huB4 and DGN462 via a cleavable disulfide linker, sulfo-SPDB. Activity of the huB4-DGN462 ADC or the unconjugated DGN462 toxin was measured in vitro using a total of 54 Lymphoma cell lines (n = 27 DLBCL; n = 10 MCL; n = 6 MZL; n = 5 ALCL; n = 6 others). Efficacy of huB4-DGN462 was also analyzed in vivo in CD19-expressing xenograft tumor models.
The poster concluding by stating that this data indicates that the novel ADC huB4-DGN462 has potent activity in preclinical models, providing cause for further study.
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Which of the following would most increase your confidence in referring patients with R/R large B-cell lymphoma for CAR T-cell therapy?