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2017-04-10T14:23:11.000Z

AACR 2017 | Poster 3724/9 – PD-L1 protein expression and tumor mutation burden correlates with Hodgkin and Diffuse Large B-Cell Lymphoma

Apr 10, 2017
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At the American Association for Cancer Research (AACR) annual meeting in Washington, DC, USA, on Tuesday 4th April, a poster session titled “Clinical Laboratory and Imaging Correlates” took place.

One of the posters on display (3724 / 9) was titled “PDL1 protein expression and tumor mutation burden in hematologic malignancies: correlation with Hodgkin and high grade lymphoma” by Lina Abdul Karim, from MedStar Georgetown University Hospital, Washington DC, and colleagues.

Immunostaining using the FDA approved PD-L1 IHC 22C3 pharmDx assay was carried out on formalin fixed paraffin embedded sections from 92 hematological malignancies including Hodgkin Lymphoma (HL), Diffuse Large B-Cell Lymphoma (DLBCL), Low-Grade Non-Hodgkin Lymphoma (LGNHL), as well as Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), and Myeloma. Partial or complete membrane staining in all viable tumor cells was scored as follows: <1% negative, 1–49% low level, and >50% high level PD-L1 expression. Comprehensive Genomic Profiling (CGP) was also done in 2,064 cases.

Key Highlights:

  • High PD–L1 expression observed 100% of HL
  • Significantly higher PD–L1 positivity was observed in DLBCL versus LGNHL (P = 0.01)
  • In CGP analysis, Tumor Mutation Burden (TMB) was significantly higher in DLBCL versus LGNHL (P < 0.0001)

The group concluded their poster by hypothesizing that the high PD-L1 expression in HL and DLBCL, and the high TMB in DLBCL, could potentially enhance responsiveness to check point inhibitor therapy.

  1. Abdul Karim L. et al. PDL1 protein expression and tumor mutation burden in hematologic malignancies: correlation with Hodgkin and high grade lymphoma [Poster]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; 2017. Poster nr [3724 / 9].

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