All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
The lym Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the lym Hub cannot guarantee the accuracy of translated content. The lym and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The Lymphoma & CLL Hub is an independent medical education platform, sponsored by AbbVie, BeOne Medicines, Johnson & Johnson, Roche, and Sobi, and supported through educational grants from Bristol Myers Squibb, Incyte, Lilly, and Pfizer. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View lym content recommended for you
At the American Association for Cancer Research (AACR) annual meeting in Washington, DC, USA, on Wednesday 5th April, a poster session titled “Anticancer Precision Clinical Pharmacology” took place.
One of the poters on display (5050 / 25) was titled “Pharmacodynamic and pharmacokinetic relationship of single agent E7449 in patients with advanced solid tumors or B-cell malignancies” by Pallavi Sachdev from Eisai, Inc., Woodcliff Lake, NJ, and colleagues.
E7449 is a small-molecule inhibitor of Poly (ADP-Ribose) Polymerase (PARP). A multicenter, open-label, phase I study was conducted aiming to identify the Maximum Tolerated Dose (MTD), safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and preliminary anti-tumor activity of single-agent E7449 (NCT01618136). In the poster, the group presented additional PD and PK results from the phase I trial.
Patients (n = 28) were 18 years or older and had measurable, confirmed, advanced solid tumors or B-Cell Lymphoma that had progressed after approved treatment. Those with Lymphoma must have R/R disease that progressed following three previous systemic treatment regimens. Eligible subtypes were MCL, MZL, FL, DLBCL, and CLL. Patients received E7449 at 50, 100, 200, 600, or 800mg/day. An expansion cohort (n = 13) was used to study food. PD assessments included measurement of PARP activity and comet assay to determine the extent of DNA damage.
The poster concluded that “these results support E7449 dosing at 600mg/day.”
References
Your opinion matters
Which of the following would most increase your confidence in referring patients with R/R large B-cell lymphoma for CAR T-cell therapy?