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This year’s American Association for Cancer Research (AACR) annual meeting took place on 1–5 April in Washington, DC, USA. The program committee Chair was Kornelia Polyak, MD, PhD, from the Dana-Farber Cancer Institute, Boston, Massachusetts.
On Monday 3rd April, a poster (CT038 / 14) by Drew Rasco, from South Texas Accelerated Research Therapeutics, San Antonio, TX, et al. titled “A phase I, open-label, dose-escalation study to investigate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of GSK3326595 in subjects with solid tumors and non-Hodgkin's lymphoma” was presented.
GSK3326595 is an orally administered, selective, and reversible Protein Arginine Methyltransferase 5 (PRMT5) inhibitor, which halts proliferation and induces apoptosis in numerous solid and hematologic tumor cell lines. It has been shown to have potent anti-tumor activity in vivo in animal models.
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