All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
Introducing
Now you can personalise
your Lymphoma Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe Lymphoma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lymphoma Hub cannot guarantee the accuracy of translated content. The Lymphoma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
Bookmark this article
This ASCO 2016 oral abstract presentation took place on Sunday June 5, 9:45am–12:45pm, during the ‘Hematologic Malignancies-Lymphoma and Chronic Lymphocytic Leukemia’ session. This session was chaired by Pr Gilles Salles, Head of the Hematology Department in South Lyon hospitals, Lyon, France.
The abstract (#7504) was presented by Dr Pieternella J Lugtenburg of Erasmus MC, Rotterdam, Netherlands.
In patients with Diffuse Large B-Cell Lymphoma (DLBCL), the standard care option is R-CHOP. However, the optimal rituximab dose and schedule is yet to be determined. A randomized, phase III study (NTR number: 1014) was initiated to compare standard R-CHOP-14 and R-CHOP-14 with 4 additional rituximab administrations (375mg/m2 IV on day 8) during the initial 4 cycles.
It was hypothesized that better response rates (CR) will be achieved in the early intensification of rituximab plus 2-weekly CHOP arm (arm B) than the standard arm (arm A). The primary endpoint was metabolic complete remission rate after induction treatment.
Inclusion criteria for this study included: confirmed histologic diagnosis of DLBCL according to WHO classification, CD20+, Ann Arbor stages II–IV, and age range of 66–80 years. Patients in CR after induction treatment were randomized between observation and rituximab maintenance.
During this talk, the efficacy results of the first randomization were presented.
Intensified compared to standard rituximab did not improve CR rate, OS or PFS. In addition, no benefit was observed in any of the clinical subgroups (age or gender). Intensification of rituximab resulted in more toxicity in patients aged between 66 and 80 years, in particular neutropenia during cycles 1–4, vs. standard rituximab. Pieternella Lugtenburg concluded the talk by stating that intensification of rituximab is of no benefit.
Understanding your specialty helps us to deliver the most relevant and engaging content.
Please spare a moment to share yours.
Please select or type your specialty
Subscribe to get the best content related to lymphoma & CLL delivered to your inbox