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On Monday 11 December 2017 during an oral abstract session at the 59th Annual meeting American Society of Hematology (ASH), Magdalena Klanova of the Charles University General Hospital in Prague, Czech Republic on behalf of her colleagues, presented results from an exploratory, post-hoc analysis of the phase III GALLIUM and GOYA clinical trials in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL).
The abstract (#727), “Low Peripheral Blood NK Cell Count Is Associated with Worse Clinical Outcome in Patients with Follicular Lymphoma (FL) and Diffuse Large B-Cell Lymphoma (DLBCL) Treated with Immunochemotherapy: Results from the Frontline Phase 3 GALLIUM and GOYA Trials,” was presented during Oral Session 622. “Lymphoma Biology—Non-Genetic Studies: Prognostic Biomarkers and Immune Mechanisms in Lymphoma”; this summary is based on data presented at this session and may supersede information in the pre-published ASH Abstract.
This was the largest prospective collection of PB NK cells to date in FL and DLBCL, in which substantial numbers of patients had reduced NKCCs at BL, which was closely correlated with advanced disease. According to the study authors, univariate and MV analyses may have suggested that low PB NKCC is independently associated with shorter PFS in FL and DLBCL and shorter OS in FL. Likewise, low NK cell gene expression in tumor tissue was associated with shorter PFS in G-treated DLBCL pts.
The collective results from this exploratory analysis indicated that the quantitative measures of NK cells in PB and tumor tissue may, in fact, play a decisive role in determining the clinical outcome of non-Hodgkin lymphoma patients treated with an anti-CD20 antibody treatment.
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