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On Saturday December 9th, 2017 during an oral abstract session at the 59th Annual meeting American Society of Hematology (ASH), Eric Eldering of the Academic Medical Center in Amsterdam, Netherlands, on behalf of his colleagues, presented results from an in vitro study in which they endeavored to understand the contribution of distinct BCL-2 family members to resistance against ibrutinib or venetoclax in chronic lymphocytic leukemia (CLL). The investigators underscored the need to further elucidate the contribution of distinct BCL-2 family members to resistance against these single drugs in order to design more effective, long-term therapy combinations.
This abstract (#262), “Dissecting the Role of Individual Bcl-2 Members in Response and Resistance to Ibrutinib or Venetoclax in CLL,” was presented during Oral Session: 641. “Biology and Pathophysiology, excluding Therapy: Therapeutic Resistance in CLL.” In the summary below, data from the live session at ASH is used and therefore may supersede information in the pre-published Abstract.
While small in size, this study strongly indicated that BCL-2 members can be used as both a drug target and markers of response and relapse. The hope is that larger studies will yield treatment strategies that leverage a combination of venetoclax and ibrutinib that prevent access to the protective LN, and perhaps establish a new, effective long-term treatment regimen in CLL.
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Which of the following would most increase your confidence in referring patients with R/R large B-cell lymphoma for CAR T-cell therapy?