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On Saturday 1 December 2018, Oral Session 626 took place at the 60th American Society of Hematology (ASH) Annual Meeting, San Diego, CA. During that session, through Abstract #228 the updated results of the Keynote-013 (KN013) phase Ib trial and the first analysis of its subsequent phase II trial Keynote-170 (KN170), were presented by Philippe Armand from the Dana-Farber Cancer Institute, Boston, MA, USA.
In the primary analysis of the phase Ib KN013 study (NCT01953692), relapsed or refractory (R/R) patients with primary mediastinal large B-cell lymphoma (PMBCL), achieved frequent and durable responses with pembrolizumab. They achieved an objective response rate (ORR) of 41% and a complete response rate of 12%. Here the investigators presented the updated results from this phase Ib trial together with the primary phase II analysis (NCT02576990) on the efficacy and safety of pembrolizumab in R/R PMBCL. Pembrolizumab is a humanized IgG4 anti-PD1 monoclonal antibody. The primary endpoint of KN170 was ORR by blinded independent central review (BICR). Secondary endpoints included, progression-free survival (PFS), overall survival (OS), and safety. Exploratory endpoints included response by Lugano 2014 criteria.
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Which of the following would most increase your confidence in referring patients with R/R large B-cell lymphoma for CAR T-cell therapy?