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On Monday 3 December 2018, during the 60th Annual Meeting of the American Society of Hematology (ASH), San Diego, CA, Laurie Sehn from British Columbia Cancer Agency, Vancouver, CA, presented the results of the phase III trial GOYA (Abstract #783; Oral Session #626).
GOYA (NCT01287741) was an international, open-label, randomized, phase III trial that compared the efficacy and safety of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) to obinutuzumab (G) plus CHOP in previously untreated patients diffuse large B-cell lymphoma (DLBCL) patients. In the primary analysis of the GOYA trial, there was no significant difference in the three-year PFS of patients receiving R-CHOP to those receiving G-CHOP. In this current secondary analysis, the assessed endpoints were investigator-assessed (INV) progression-free survival (PFS), and overall survival (OS) in patients receiving six cycles of CHOP (CHOP6) versus eight cycles of CHOP (CHOP8). Secondary endpoint was safety of CHOP6 versus CHOP8.
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