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The management of advanced-stage Hodgkin’s lymphoma (HL) has improved over the past few decades as a result of modern onco-hematology. However, challenges remain such as balancing the advantage of early disease control against the disadvantage of late toxicity of the most commonly used first-line chemotherapy regimen; doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD).
A phase I dose-escalation study2 evaluating the use of frontline brentuximab vedotin (A) combined with either ABVD or doxorubicin, vinblastine, and dacarbazine (AVD) in patients with advanced Hodgkin’s lymphoma showed superior results for brentuximab plus AVD. Based on these findings, ECHELON-1, a large, international, open-label, randomized, multicenter, phase III study was conducted to compare A plus AVD with ABVD as frontline therapy in patients with stage III or IV classic Hodgkin’s lymphoma.
Results from the ECHELON-1 phase III study were presented during a plenary scientific session at the 59th Annual Meeting & Exposition of the American Society of Hematology (ASH) in Atlanta, GA, on December 10th, 2017. The talk was presented by Joseph M. Connors, MD, Division of Medical Oncology and Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, Canada. This article is based on data presented at the live session and the publication in The New England Journal of Medicine.
Doctor Connors concluded by stating that the results of the ECHELON-1 trial showed “significantly superior modified PFS with brentuximab vedotin in combination with AVD compared to standard treatment with ABVD. Moreover, A+AVD showed a manageable toxicity profile.” The presenter also added that these results are particularly important as A+AVD offers an effective treatment to older patients.
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