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For patients with relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL), standard salvage therapy consists of high-dose chemotherapy followed by autologous stem cell transplantation (auto-HSCT); however, the efficacy of conventional salvage chemotherapy treatment can vary.1 Camrelizumab, a humanized IgG4 monoclonal antibody targeting PD-1, has demonstrated efficacy in patients with R/R cHL based on long-term results from a phase II trial (NCT03155425).1
Here, we summarize results from a phase II trial (NCT04239170) assessing the safety and efficacy of camrelizumab, in combination with the gemcitabine and oxaliplatin (GEMOX) chemotherapy regimen, followed by auto-HSCT in patients with R/R cHL, recently published Liu et al.1 in BMC Medicine.1
Upon completion of the protocol therapy, the CR rate was 64.3% (Figure 1).
Figure 1. Response rates after protocol therapy*
*Data from Liu, et al.1
†Includes all patients who received at least one dose of the study drug.
‡Includes patients with at least one posttreatment response evaluation.
Grade 3 treatment-emergent adverse events occurred in 28.6% of patients (Table 1).
Table 1. TEAEs occurring in ≥5% of patients*
TEAEs, % |
Any grade |
Grade 1 |
Grade 2 |
Grade 3 |
Grade 4 |
≥1 TEAE |
97.6 |
16.7 |
50.0 |
28.6 |
2.4 |
ALT increased |
57.1 |
52.4 |
2.4 |
2.4 |
0 |
Neutrophil count decreased |
47.6 |
14.3 |
19.0 |
14.3 |
0 |
Vomiting |
45.2 |
23.8 |
19.0 |
2.4 |
0 |
Nausea |
42.9 |
40.5 |
2.4 |
0 |
0 |
White blood cell decreased |
38.1 |
9.5 |
21.4 |
4.8 |
2.4 |
AST increased |
35.7 |
31.0 |
4.8 |
0 |
0 |
RCCEP |
35.7 |
35.7 |
0 |
0 |
0 |
Hypertriglyceridemia |
35.7 |
31.0 |
2.4 |
2.4 |
0 |
Platelet count decreased |
35.7 |
26.2 |
4.8 |
4.8 |
0 |
Hyperuricemia |
14.3 |
14.3 |
0 |
0 |
0 |
LDH increased |
11.9 |
11.9 |
0 |
0 |
0 |
Anemia |
11.9 |
11.9 |
0 |
0 |
0 |
Fever |
9.5 |
9.5 |
0 |
0 |
0 |
Infectious pneumonia |
9.5 |
0 |
9.5 |
0 |
0 |
Interstitial pneumonia |
9.5 |
0 |
4.8 |
4.8 |
0 |
Pruritus |
9.5 |
7.1 |
2.4 |
0 |
0 |
Anorexia |
9.5 |
9.5 |
0 |
0 |
0 |
Hypokalemia |
7.1 |
7.1 |
0 |
0 |
0 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; RCCEP, reactive cutaneous capillary endothelial proliferation; TEAE, treatment-emergent adverse events. |
Key learnings |
These results indicate that camrelizumab in combination with GEMOX is an effective salvage therapy with a tolerable safety profile in patients with R/R cHL, allowing patients to proceed to auto-HSCT consolidation. |
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