All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
The lym Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the lym Hub cannot guarantee the accuracy of translated content. The lym and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The Lymphoma & CLL Hub is an independent medical education platform, sponsored by AbbVie, BeOne Medicines, Johnson & Johnson, Roche, and Sobi, and supported through educational grants from Bristol Myers Squibb, Incyte, Lilly, and Pfizer. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View lym content recommended for you
In May 2016, Glass et al. published in the Journal of Clinical Oncology the results of a phase I/II study into the efficacy of methotrexate, temozolomide (TMZ) with rituximab, proceeded by hyperfractionated Whole-Brain Radiotherapy (hWBRT) in patients with Primary CNS Lymphoma (PCNSL), followed by maintenance treatment with TMZ. The reported 2-year OS and PFS were 80.8% and 63.6%, respectively.
In a more recent correspondence, also in the Journal of Clinical Oncology, Marc C. Chamberlain, of the University of Washington and Fred Hutchinson Cancer Research Center, Seattle, responded to these results explaining potential issues with the study. The key points of concern were:
In conclusion, both the authors of the original study and Marc Chamberlain state that randomized trials are needed to elucidate the value of these protocol modifications for treatment of PCNSL. Marc Chamberlain also suggested that deciding upon which regimen a patient should follow is based on “interpretation of a confusing literature”, and the physician’s familiarity with and subjective opinions of therapies, amplifying the need for more randomized, multi-arm studies.
References
Your opinion matters
Which of the following would most increase your confidence in referring patients with R/R large B-cell lymphoma for CAR T-cell therapy?