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At the oral session on lymphoma at the 44th European Society for Blood and Marrow Transplantation (EBMT) annual meeting on 19 March 2018, Abstract OS1-5 was presented by Nobuaki Nakano from the Imamura General Hospital, Kagoshima, Japan, on behalf of the Japanese Society for Hematopoietic Cell Transplantation (JSHCT) ATL working group. During this oral presentation, the impact of chromosomal abnormalities on adult T-cell leukemia/lymphoma (ATL) patients’ survival following allogeneic HSCT (allo-HSCT) was discussed.
Results from their previous study reported the deleterious effects of chromosomal abnormalities on the survival of newly-diagnosed ATL patients, who received conventional chemotherapy but not allo-HSCT. Building upon these outcomes, the authors performed a large scale evaluation of the presence and effects of chromosomal abnormalities on the survival of ATL patients from the Transplant Registry Unified Management Program (TRUMP) that received allo-HSCT. The primary endpoint of the study was overall survival (OS).
This study demonstrated the existence of multiple numerical and structural chromosomal abnormalities in samples from a large cohort of ATL patients that received allo-HSCT. Moreover, evidence was provided for the negative impact of certain chromosomal abnormalities on ATL patient survival, like break points at 2q and 5q that were negatively-associated with OS. These breakpoints represented independent risk factors for OS in ATL patients post allo-HSCT.
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