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EHA 2019 | AUGMENT study: Post-hoc analysis in MZL

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At the 24th Congress of the European Hematology Association (EHA), Catherine Thieblemont from the Hôpital Saint-Louis, Paris, FR, shares a post-hoc analysis from the AUGMENT study in marginal zone lymphoma (MZL).

The AUGMENT study was a randomized study in patients with relapsed/refractory follicular lymphoma (FL) or MZL (20% of patients, n = 63). Patients were randomized to either R2 (rituximab and lenalidomide) or rituximab and placebo. The primary endpoint was progression-free survival (PFS).
At baseline, patients in the R2 arm had bulkier disease and there were significant differences in these baseline characteristics between the two arms. However, in the R2 arm, there was a higher overall response rate (65%) compared to rituximab and placebo (43%). This did not translate to differences in PFS.

AUGMENT study: Post-hoc analysis in MZL

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