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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
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This article was written by Dr Andre Goy from the John Theurer Cancer Center, HUMC, Hackensack, NJ along with his colleagues and was published in the British Journal of Haematology in August 2016. The article evaluates the safety and efficacy of inotuzumab ozogamicin (InO, CMC-544) as a single agent in patients with indolent B-cell non-Hodgkin's lymphoma, who were refractory to rituximab alone, rituximab in combination with chemotherapy or anti-CD20 radioimmunotherapy (RIT). (www.clinicaltrials.gov, NCT00868608).
In this study, InO demonstrated anti-tumor activity, which was observed across all the patient subgroups. MZL or SLL patients responded less to InO when compared to FL patients and therefore, the small sample size of MZL and SLL patients (4 and 5, respectively), makes the results difficult to analyse. Future studies are need to establish if different dosing regimens would reduce toxicity, increase efficacy and longer treatment duration in iNHL patients.
A phase 2 study of inotuzumab ozogamicin in patients with indolent B-cell non-Hodgkin lymphoma refractory to rituximab alone, rituximab and chemotherapy, or radioimmunotherapy
This phase 2 study evaluated the efficacy and safety of inotuzumab ozogamicin (InO) in patients with indolent B-cell non-Hodgkin lymphoma (NHL) refractory to rituximab alone, rituximab plus chemotherapy or antiCD20 radioimmunotherapy. Patients received InO 1.8 mg/m2 intravenously on a 28-d cycle for a planned 4–8 cycles. The initial InO dose and schedule could be adjusted for tolerability and patients were allowed to receive 2 additional cycles (up to 8 total) after achieving a complete response (CR). The primary endpoint was overall response. Eighty-one patients were enrolled, among whom 48 (59%) received ≥3 InO cycles and 13 (16%) completed the treatment phase. The overall response rate was 67% (CR, 31%). Median (95% confidence interval) progression-free survival was 12.7 (8.9–26.9) months; median overall survival was not reached. Haematological adverse events (AEs) were common, particularly thrombocytopenia (74%) and neutropenia (56%). These were also the most common AEs leading to treatment discontinuation (37% and 11%, respectively); 58% of patients reported AEs leading to treatment discontinuation. InO demonstrated robust activity in these heavily pretreated patients, although treatment duration was limited by haematological toxicities. Additional studies may determine dosing regimens that allow for reduced toxicity.
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