All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
The lym Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the lym Hub cannot guarantee the accuracy of translated content. The lym and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The Lymphoma & CLL Hub is an independent medical education platform, sponsored by AbbVie, BeOne Medicines, Johnson & Johnson, Roche, and Sobi, and supported through educational grants from Bristol Myers Squibb, Incyte, Lilly, and Pfizer. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View lym content recommended for you
Dr Francesc Graus from the Neurology Service Hospital Clinic, Barcelona, Spain, presented a session based on results from a range of multidisciplinary studies focused on identifying optimal treatment regimens for patients with Primary Central Nervous System Lymphoma (PCNSL) at the ESMO congress 2016, at Copenhagen, Denmark.
Dr Graus discussed, through the presentation of the case studied, the main questions raised for the treatment of a primary CNS lymphoma.
The role of chemoimmunotherapy was confirmed by the IELSG phase 2 trial published recently by Ferreri et al. in the Lancet Hematology. 219 PCNSL patients were given either MTX/cytarabine alone or in combination with rituximab, or rituximab and thiotepa. The primary outcome of this trial was to compare the complete response of participants to the different treatment regimes. The trial results showed that patients treated with rituximab plus thiotepa had a CRR of 49% compared with 23% for MTX/cytarabine alone and 30% for MTX/cytarabine/rituximab.
Finally, the question of treatment options for PCNSL relapses was raised. One study with a primary outcome to investigate MTX re-challenge to 39 PCNSL patients who responded previously to MTX therapy and experienced relapse was presented. The trial data revealed that the 1-year OS was 79% and the median OS was 41 months, thus suggesting MTX re-challenge is effective in relapsed PCNSL patients.
On-going clinical trials are underway for patients with either relapsed or progressive PCNSL using different therapeutic agents and the results in terms of OS are promising.
Your opinion matters
Which of the following would most increase your confidence in referring patients with R/R large B-cell lymphoma for CAR T-cell therapy?