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In a letter to the editor of Blood published online in July ahead of print, Joseph M. Connors, of the British Columbia Cancer Agency Centre for Lymphoid Cancer and the University of British Columbia, Vancouver, Canada, and colleagues presented five-year follow-up data on the use of Brentuximab Vedotin (BV) in combination with ABVD or AVD in a cohort of 51 previously untreated advanced stage classical Hodgkin Lymphoma patients. In the previously reported data set from this study it was concluded that the addition of BV to ABVD in HL patients resulted in ‘excessive pulmonary toxicity’ when compared to patients being treated with this combination, but without bleomycin2. A follow-up study was therefore instigated to determine the longer-term safety and efficacy data comparing BV with either ABVD or AVD.
In conclusion, the authors stated that the combination of AVD+BV is safe, and results in ‘excellent and durable control’ of cHL. The authors also state that the possible superiority of the combination of AVD+BV compared with ABVD alone is being assessed in the ECHELON trial.
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