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Is CNS prophylaxis warranted in DLBCL?

Nov 11, 2022
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Learning objective: After reading this article, learners will be able to cite a new clinical development in DLBCL.

During the COLYM 2022 Annual Meeting, the Lymphoma Hub spoke with Matthew Wilson, Beatson West of Scotland Cancer Centre, Glasgow, UK. We asked, Is central nervous system (CNS) prophylaxis warranted in DLBCL?

Is CNS prophylaxis warranted in DLBCL?

Wilson discusses the topic of CNS relapse in DLBCL and explains that there is a lack of data in support of a clear prophylactic treatment strategy. Wilson summarizes the latest data for the use of high-dose methotrexate and describes how it is may be used sparingly. Advancements in novel molecular techniques to screen patients at baseline for CNS disease hold great promise for guiding future prophylactic treatment regimens.

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