Is peripheral neuropathy in patients with DLBCL more severe after pola-R-CHP vs R-CHOP treatment?

During the EHA 2022 Congress, the Lymphoma Hub spoke with Marek Trněný, Charles University, Prague, CZ. We asked, Is peripheral neuropathy in patients with diffuse large B-cell lymphoma (DLBCL) more severe after pola-R-CHP vs R-CHOP treatment?

Trněný begins by outlining the POLARIX study, which showed significant improvement in progression-free survival (PFS) for patients treated with pola-R-CHP vs R-CHOP. Trněný highlights findings on the toxicity profile, and underlines the need for increased research into the effect that peripheral neuropathy has on quality of life. Also, Trněný discusses the findings of his study, including incidence and duration of peripheral neuropathy in both treatment arms.