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IWWM-12: What are the implications of iStopMM for MM and WM?

By Jennifer Reilly

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Sæmundur RögnvaldssonSæmundur Rögnvaldsson

Nov 28, 2024

Learning objective: After reading this article, learners will be able to cite a new clinical development in Waldenström’s macroglobulinemia.


During the 12th International Workshop on Waldenstrom's Macroglobulinemia (IWWM-12), the Lymphoma Hub was pleased to speak to Sæmundur Rögnvaldsson, University of Iceland, Reykjavik, IS. We asked about the iStopMM study and the implications of these data for both patients with multiple myeloma (MM) and those with Waldenstrom's macroglobulinemia (WM).

Lym + MM hub Sæmundur Rögnvaldsson iSTOPMM in MM and WM

In this interview, Rögnvaldsson discusses his role in the iStopMM (NCT03327597) study, which screens for monoclonal gammopathies (MGUS) to detect early MM and WM. Rögnvaldsson highlights the key findings, including the potential for early diagnosis to reduce disease severity and hospitalizations. Rögnvaldsson also covers the study's long-term goals, including refining follow-up, developing predictive models for progression, and understanding the biological processes behind benign versus malignant conditions. He concludes with a look at how these data could help improve outcomes in both MM and WM through optimized treatment and disease management.

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As a result of this content, I commit to reviewing the latest data from clinical trials of novel therapies for the treatment of Waldenstrom’s macroglobulinemia.

This educational resource was independently supported by BeiGene. All content was developed by SES in collaboration with an expert steering committee; funders were allowed no influence on the content of this resource

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