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The Lymphoma Hub Satellite Symposium at 15-ICML brought together an international panel of experts to discuss the novel chemotherapy-free treatment approaches for lymphoid malignancies. Professor Michael Hallek, University Hospital of Cologne, Cologne, DE, provided his thoughts on chemotherapy-free regimens for CLL.
Lymphoma Hub Satellite Symposium 2019 | CLL - chemotherapy-free regimens - Michael Hallek
The Alliance North American Intergroup Study (AO41202) did not find ibrutinib and rituximab to be better than rituximab and bendamustine. Prof. Hallek went on to present recent results from the CLL14 trials by the GCLLSG. In this study older or unfit patients benefited more from a chemotherapy-free treatment with obinutuzumab and venetoclax in terms of PFS than from chlorambucil and obinutuzumab (a summary of two abstracts presented at the 24th European Hematology Society (EHA) meeting and the 15-ICML are summarised here). In his concluding remarks, Prof. Hallek presented his recommendations regarding front-line CLL treatments:
He went on to advocate caution when using triplet combinations due to the higher risk of side effects.
Download Prof. Michael Hallek's slides:
These slides were presented by Prof. Michael Hallek during the first Lymphoma Hub Satellite Symposium at 15-ICML.Download as PDF
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