All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.

The Lymphoma Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

Introducing

Now you can personalise
your Lymphoma Hub experience!

Bookmark content to read later

Select your specific areas of interest

View content recommended for you

Find out more
  TRANSLATE

The Lymphoma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lymphoma Hub cannot guarantee the accuracy of translated content. The Lymphoma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

Steering CommitteeAbout UsNewsletterContact
LOADING
You're logged in! Click here any time to manage your account or log out.
LOADING
You're logged in! Click here any time to manage your account or log out.
2020-11-11T14:57:22.000Z

NICE recommends venetoclax + obinutuzumab for frontline treatment of CLL

Nov 11, 2020
Share:

Bookmark this article

On November 10, 2020, the National Institute for Health and Care Excellence (NICE) recommended venetoclax in combination with obinutuzumab for patients with previously untreated chronic lymphocytic leukemia (CLL).

The guidance published by NICE indicates the routine National Healthcare Service (NHS) use of the venetoclax combination for the following indications:

  • Adult patients with CLL with del(17p)/TP53 mutation

or

  • Adult patients with CLL without del(17p)/TP53 mutation who are ineligible for treatment with fludarabine, cyclophosphamide, and rituximab (FCR) or bendamustine and rituximab (BR)

NICE has also recommended the use of venetoclax + obinutuzumab within the Cancer Drugs Fund for adult patients with CLL without del(17p)/TP53 mutation who are eligible for FCR or BR.

This approval provides a chemotherapy-free, 1-year fixed duration, first-line treatment option for patients with CLL, and will be available immediately to NHS patients in England.

The decision follows positive data from the phase III CLL14 trial (NCT02242942), which uncovered the superiority of venetoclax + obinutuzumab over chlorambucil + obinutuzumab in prolonging progression-free survival in patients with previously untreated CLL. For a comprehensive summary of the study design and efficacy outcomes from the CLL14 study, click here. The Lymphoma Hub also provided an overview of the full safety profile of the two regimens employed in the CLL14 trial, read it here.

  1. NewsCision/Abbvie. NICE gives green light for chemotherapy-free combination, Venclyxto® (venetoclax) plus obinutuzumab for all front-line patients with chronic lymphocytic leukaemia (CLL). https://news.cision.com/abbvie/r/nice-gives-green-light-for-chemotherapy-free-combination--venclyxto---venetoclax--plus-obinutuzumab-,c3234026. Published Nov 10, 2020. Accessed Nov 11, 2020.

Understanding your specialty helps us to deliver the most relevant and engaging content.

Please spare a moment to share yours.

Please select or type your specialty

  Thank you

Newsletter

Subscribe to get the best content related to lymphoma & CLL delivered to your inbox