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Phase II study of loncastuximab tesirine, a novel antibody–drug conjugate, in R/R DLBCL

By Claire Baker

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Carmelo Carlo-StellaCarmelo Carlo-Stella

Jun 29, 2020


During the 25th Congress of the European Hematology Association (EHA), the Lymphoma Hub spoke to Carmelo Carlo-Stella, Humanitas University, Milan, IT, who discussed the phase II study of loncastuximab tesirine in relapsed/refractory diffuse large B-cell lymphoma.

Loncastuximab tesirine is a novel, CD19-directed, antibody–drug conjugate. In this interview, Carmelo Carlo-Stella describes the mechanism of action of this emerging agent and outlines the clinical studies evaluating loncastuximab tesirine for the treatment of relapsed/refractory diffuse large B-cell lymphoma.

Phase 2 study of loncastuximab tesirine, a novel antibody–drug conjugate, in R/R DLBCL

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What is your preferred therapy class when planning treatment for a patient with R/R DLBCL after 2 or more lines of systemic therapy ?