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POLARIX: How does MYC and BCL2 expression impact outcomes post frontline treatment with PV in DLBCL?

Jul 22, 2022
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Learning objective: After reading this article, learners will be able to cite a new clinical development in DLBCL.

During the EHA 2022 Congress, the Lymphoma Hub spoke with Gilles Salles, Memorial Sloan Kettering Cancer Center, New York, US. We asked, POLARIX trial: How does MYC and BCL2 expression impact outcomes post frontline treatment with polatuzumab vedotin (PV) in diffuse large B-cell lymphoma (DLBCL).

POLARIX: How does MYC and BCL2 expression impact outcomes post frontline treatment with PV in DLBCL?

Salles discusses the activity of the combination polatuzumab vedotin + rituximab-CHOP in patients with DLBCL, and some chromosomal abnormalities. Salles outlines the consequences of BCL2 overexpression on treatment outcomes, and the improvement that this combination has shown for this patient group.