All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
In March 2018, Xiaojun Huang from Peking University People's Hospital, Beijing, China, and colleagues published the results of a randomized open-label phase III trial (NCT01973387) on ibrutinib versus rituximab for relapsed/refractory (R/R) patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Cancer Medicine.
Despite the global advances in therapies for CLL/SLL patients, treatment options remain limited in the Asia-Pacific region and especially for difficult-to-treat R/R patients. In China, R/R CLL/SLL patients that do not respond to traditional chemotherapy are limited to rituximab or lenalidomide/thalidomide containing regimens. The aim of this trial was to evaluate the efficacy and safety of ibrutinib versus rituximab for the treatment of R/R CLL/SLL. The primary endpoints of the study were investigator-assessed progression-free survival (PFS), while secondary endpoints included overall response rate (ORR), overall survival (OS), and safety.
The results of this phase III clinical trial indicate the superiority of ibrutinib over rituximab for the treatment of R/R CLL/SLL patients in the Asia-Pacific region. With similarly acceptable safety profiles, ibrutinib improved PFS, ORR and OS, when compared to rituximab treatment. According to the authors, these results are consistent with other global studies, indicating that ibrutinib’s efficacy and safety over rituximab is comparable to the values observed for the general population.
Updated results from the phase III HELIOS trial for relapsed or refractory CLL/SLL
The three-year follow-up data from the phase III clinical trial HELIOS are suggestive of the prolonged survival benefit of ibrutinib-based therapy for R/R CLL/SLL...
Ibrutinib with bendamustine and rituximab in R/R CLL/SLL: Final 5-year results from the HELIOS trial
Ibrutinib is a first-in-class Bruton’s tyrosine kinase (BTK) inhibitor that has been approved to treat various B-cell malignancies in adults. It is...
Subscribe to get the best content related to lymphoma & CLL delivered to your inbox