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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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Follow-up data obtained from the TRANSCEND NHL 001 trial (NCT02631044) demonstrates that treatment with lisocabtagene maraleucel (liso-cel) leads to long-lasting responses in patients with relapsed/refractory large B-cell lymphoma. Below, we summarize the data as presented at the 2022 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR[MM1] .1
Liso-cel is an autologous, CD19-directed, defined composition, 4-1BB chimeric antigen receptor (CAR) T-cell product administered at equal target doses of CD8+ and CD4+ T cells. The therapy was recently approved by the European Commission as a ≥third-line treatment for certain forms of relapsed or refractory large B-cell lymphoma.
At the 2-year follow-up, the TRANSCEND NHL 001 study met all of its primary and secondary endpoints.
Of the 269 patients who received liso-cel, 257 were evaluable for efficacy:
In conclusion, liso-cel demonstrated durable remission rates and a promising safety profile in the 2-year follow-up of TRANSCEND NHL 001. Treatment was associated with a low incidence of severe cytokine release syndrome and neurological events. There were no additional safety concerns observed in this follow-up, and most of the adverse events occurred in the treatment-emergent reporting period.
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