All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
Introducing
Now you can personalise
your Lymphoma Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe Lymphoma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lymphoma Hub cannot guarantee the accuracy of translated content. The Lymphoma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
Bookmark this article
Vitamin D, a precursor of the corticosteroid hormone calcitriol, is not only important for appropriate calcium homeostasis and bone heath, but some studies suggest that its higher levels are associated with lower risk of developing certain types of cancer.1,2 Recently, the incidence of Hodgkin lymphoma (HL) has been demonstrated to peak during early spring, which coincides with lower levels of vitamin D after winter months due to insufficient exposure to the UVB irradiation required for vitamin D synthesis.3–5 Sven Borchmann and colleagues carried out a randomized, case-controlled study to further evaluate the association between vitamin D deficiency and the incidence of HL, as well as its impact on patients’ mortality.6
* summer versus other seasons; IPS, International Scoring System | ||||
|
Deficient |
Insufficient |
Sufficient |
P |
---|---|---|---|---|
Median age |
32 (16–75) |
33 (17–71) |
31 (16–66) |
0.73 |
Sex Female Male |
73 (42) 102 (58) |
27 (33) 56 (67) |
41 (44) 52 (56) |
0.21 |
Diagnosis season Summer Autumn Winter Spring |
33 (19) 36 (21) 52 (30) 54 (31) |
21 (25) 17 (20) 16 (19) 29 (35) |
43 (46) 22 (24) 13 (14) 15 (16) |
<0.0001* |
IPS <2 ≥2 |
88/129 (68) 41/129 (32) |
53/71 (75) 18/71 (25) |
64/84 (76) 20/84 (24) |
0.52 |
Based on preclinical and clinical data, the authors advocate for further clinical trials in patients with HL to include monitoring of vitamin D levels and supplementation to further elucidate its role in control of HL.
Understanding your specialty helps us to deliver the most relevant and engaging content.
Please spare a moment to share yours.
Please select or type your specialty
Subscribe to get the best content related to lymphoma & CLL delivered to your inbox