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What is the most promising novel agent for the treatment of aggressive B-cell lymphoma?
Featured:
Gilles SallesDuring the Society of Hematologic Oncology (SOHO) 2021 Annual Meeting, the Lymphoma Hub was pleased to speak to Gilles Salles, Memorial Sloan Kettering Cancer Center, US. We asked, What is the most promising novel agent for the treatment of aggressive B-cell lymphoma?
What is the most promising novel agent for the treatment of aggressive B-cell lymphoma?
Salles begins by discussing new Bruton's tyrosine kinase inhibitors in the field, IRAK4 and a new protein degrading family of molecules. He describes the anticipation within the field for the final results of the POLARIX study, investigating polatuzumab vedotin. He then discusses tafasitamab, lenalidomide, and the L-MIND trial. Finally, he outlines complete response and overall response rates in the active development of bispecific antibodies such as glofitimab.
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This content is accurate as of the date of publication and is not updated retrospectively. Please refer to the latest available evidence, guidelines, and relevant regulatory information when making clinical decisions.
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When selecting the next therapy for patients with R/R MCL after BTKi progression, what is your most important consideration?