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What predicts disease progression on venetoclax?

During the Society of Hematologic Oncology (SOHO) 2021 Annual Meeting, the Lymphoma Hub was pleased to speak to Constantine Tam, Peter MacCallum Cancer Centre, Melbourne, AU. We asked, What predicts disease progression on venetoclax?

What predicts disease progression on venetoclax?

Tam begins by discussing the clinical and genetic factors that predispose a patient to progressing on venetoclax. These include traditional risk factors for chronic lymphocytic leukemia and P53 dysfunction, covered in studies such as CLL14 and MURANO. Finally, he discusses the mechanisms of resistance to venetoclax, describing how many patients who develop resistance have a spectrum of Bcl-2 mutations.