PCNSL

What should be done for elderly patients with primary central nervous system lymphoma?

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At the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, Matthias Holdhoff, Johns Hopkins University, discusses the treatment options for elderly patients with primary central nervous system (CNS) lymphoma. Dr. Holdhoff explains how over 50% of patients who are diagnosed are 60 years or older. The outcomes for patients who are treated for primary central nervous lymphomas has significantly improved over the last 4 decades, partly due to more aggressive therapies that have been tolerated reasonably well. Dr. Holdhoff then goes on to explain how the term elderly has evolved over time, as patients tend to live longer and comorbidities can be better managed, as well as how giving therapy with high dose methotrexate can very well be tolerated in old or very old patients.