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What treatment options are there for patients with CLL who are resistant to both BTKi and BCL2i?

Apr 3, 2022
Learning objective: After reading this article, learners will be able to cite a new clinical development in lymphoma/CLL

During the ESH Translational Research Conference, the Lymphoma Hub was pleased to speak with Lukas Frenzel, University Hospital of Cologne, Cologne, DE. We asked, What treatment options are there for patients with chronic lymphocytic leukemia (CLL) who are resistant to both BTK inhibitor (BTKi) and BCL2 inhibitor (BCL2i)?

What treatment options are there for patients with CLL who are resistant to both BTKi and BCL2i?

Frenzel begins by defining double-refractory CLL and a sequential treatment regimen, followed by a discussion on first-line and next-line therapeutic options, stressing the importance of understanding the mode of resistance and further clinical trials. Frenzel then highlights a need to target MCL1, despite toxicities shown in trials. Finally, Frenzel explores cellular therapies, such as CAR T-cell therapy or bispecific antibodies, as ways to overcome resistance.

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