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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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Results from the phase III ECHO trial (NCT02972840) of acalabrutinib (A) plus bendamustine (B) and rituximab (R) vs placebo (Pbo) plus B and R in patients with newly diagnosed mantle cell lymphoma (MCL) were presented at the European Hematology Association (EHA) 2024 Hybrid Congress by Michael Wang.1 |
Key learnings: |
The phase III ECHO trial met its primary endpoint of progression-free survival (PFS). |
With a median follow-up of 45 months (mo), the PFS was 66.4 mo vs 49.6 mo in the A+B+R and Pbo+B+R arms, respectively (p = 0.0160). |
Overall response rates were 91% (complete response [CR], 66.6%) vs 88% (CR, 53.5%) in the A+B+R and Pbo+B+R arms, respectively. |
Overall survival (OS) was not reached in the A+B+R or Pbo+B+R arms (HR, 0.86; 95% confidence interval [CI], 0.65–1.13; p = 0.2743). |
The safety profile of A+B+R was consistent with that of the individual agents. |
Gr ≥3 AEs were comparable between A+B+R and Pbo+B+R arms, and AEs of clinical interest were:
|
The ECHO trial results suggest that addition of A to B+R could improve outcomes for older patients with newly diagnosed MCL when given as a frontline therapy. |
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