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Visual abstract | Auto-HSCT after a rituximab/ibrutinib/Ara-c containing induction in generalized mantle cell lymphoma: TRIANGLE trial
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The Lymphoma Hub is pleased to present a visual abstract summarizing results from the phase III TRIANGLE trial (NCT02858258) assessing the safety and efficacy of the addition of ibrutinib, a Bruton’s tyrosine kinase inhibitor, to standard immunochemotherapy with or without autologous hematopoietic stem cell transplantation (auto-HSCT) in younger patients with mantle cell lymphoma. Results from this trial were published by Dreyling et al.1 in The Lancet.
The addition of ibrutinib to standard immunochemotherapy improved outcomes; however, toxicity was increased when ibrutinib was given after auto-HSCT.1 Whether auto-HSCT is beneficial with ibrutinib-based treatment is yet to be determined.1
- Dreyling M, Doorduijn J, Giné E, et al. Ibrutinib combined with immunochemotherapy with or without autologous stem-cell transplantation versus immunochemotherapy and autologous stem-cell transplantation in previously untreated patients with mantle cell lymphoma (TRIANGLE): a three-arm, randomised, open-label, phase 3 superiority trial of the European Mantle Cell Lymphoma Network. 2024. Online ahead of print. DOI: 10.1016/S0140-6736(24)00184-3.
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