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On Friday 15th June an oral abstract session took place at the 23rd Congress of the European Hematology Association (EHA). Abstract S102 was presented by Mathias Rummel, University Hospital Giessen, Germany, on the outcomes of the StiL NHL7-2008 MAINTAIN trial.
The MAINTAIN trial is a prospective, randomized, multi-center phase II study assessing two-years rituximab maintenance compared with observation after first-line treatment with bendamustine plus rituximab (B-R) in patients with non-Hodgkin lymphoma (NHL) and small lymphocytic leukemia. The results presented focused on patients with marginal zone lymphoma (MZL). The objective of the StiL NHL7-2008 study was to demonstrate progression-free survival (PFS) improvement of 2-year rituximab maintenance over observation after induction with B-R.
Dr Rummel concluded that the 2 years R-maintenance cohort had prolonged PFS after B-R but there was no statistically significant difference in OS between the two groups. He noted that the study confirmed high anti-lymphoma activity of B-R in patients with MZL. Additionally, Dr Rummel said that B-R followed by R-maintenance appeared to be a very effective treatment approach in patients with nodal and splenic MZL.
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Which of the following would most increase your confidence in referring patients with R/R large B-cell lymphoma for CAR T-cell therapy?