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Treating classical Hodgkin lymphoma: Spotlight on targeted therapies
with Gilles Salles, Paul Bröckelmann, and Ann S. LaCasce
Saturday, November 2, 2024
8:50-9:50 CET
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On 26 November 2018, mogamulizumab, a humanized monoclonal antibody directed against the CC chemokine receptor 4 (CCR4), received marketing authorization from the European Medicines Agency (EMA) for the treatment of adult patients with previously treated cutaneous T-cell lymphoma (CTCL), mycosis fungoides (MF) or Sézary syndrome (SS), who have received at least one prior systemic therapy.
The approval granted by the EMA was based on positive results from the international, open-label, randomized, controlled, phase III MAVORIC trial (NCT01728805) comparing mogamulizumab with vorinostat in patients with previously treated MF and SS. Mogamulizumab therapy resulted in superior investigator-assessed progression-free survival in the intent-to-treat population compared with vorinostat therapy (median 7.7 months [95% CI, 5.7–10.3] versus 3.1 months [95% CI, 2.9–4.1] respectively, P < 0.0001).
The phase III trial investigators concluded that mogamulizumab could provide a new, effective treatment for patients with MF and, importantly, for SS, a subtype that represents a major therapeutic challenge in CTCL.
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