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Histone deacetylation is an epigenetic process involved in the regulation of gene expression. Histone acetyltransferases and histone deacetylases (HDACs) have opposite functions, but both are involved in regulating a variety of oncogenic processes. HDAC inhibitors have anti-tumour activity and are used in various indications, such as T-cell lymphomas and mantle cell lymphoma (MCL).