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Chemokine receptor antagonists

Chemokine receptor antagonists

Chemokine receptor  antagonists  are small molecules that selectively bind to a specific chemokine receptor on  tumor  or stromal cells. The binding leads to the inhibition of the receptor’s  signaling  pathway ,   which may lead to inhibition of various functions, such as  immune cell  recruitment and activation,  stem cell homing,  angiogenesis, cancer cell proliferation, and metastasis.

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