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Checkpoint inhibitors
Checkpoint inhibitors
Checkpoint inhibitors target molecules responsible for the regulation of the immune response. The expression of programmed cell death protein 1 (PD-1) and its ligand, PD-L1, suppresses T cells in Hodgkin lymphoma. In response to a normal immune challenge, this pathway prevents hyperstimulation, and in malignancy this can halt immune responses, enabling unimpeded tumor progression.