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mTOR inhibitors inhibit the mammalian target of rapamycin (mTOR) by forming a complex with binding proteins and preventing the phosphorylation of mTOR substrates. The inhibition of mTOR leads to cell cycle arrest and inhibits angiogenesis. The mTOR inhibitor, temsirolimus, is approved for the treatment of relapsed or refractory mantle cell lymphoma (MCL).
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