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Proteasome inhibitors
Proteasome inhibitors
Proteasome inhibitors bind to the proteasome and prevent degradation of multiple proteins involved in various signaling cascades. In lymphomas, the accumulation of unfolded proteins in the endoplasmic reticulum triggers several pro-apoptotic factors and cell stress, thereby inducing apoptosis. Typical examples of proteasome inhibitors are bortezomib and carfilzomib.