All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
The Lymphoma Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy
The Lymphoma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lymphoma Hub cannot guarantee the accuracy of translated content. The Lymphoma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
Proteasome inhibitors
Proteasome inhibitors
Proteasome inhibitors bind to the proteasome and prevent degradation of multiple proteins involved in various signaling cascades. In lymphomas, the accumulation of unfolded proteins in the endoplasmic reticulum triggers several pro-apoptotic factors and cell stress, thereby inducing apoptosis. Typical examples of proteasome inhibitors are bortezomib and carfilzomib.
Save to your areas of interest