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Nuclear export inhibitors
Nuclear export inhibitors
Inhibition of nuclear export is broadly applicable to the field of hemato-oncology. Exportin 1 (XPO1) is the nuclear transporter exporting most tumor suppressor and growth regulatory factors, and is upregulated in many malignancies conferring a poor prognosis. XPO1 inhibition, with selective inhibitors of nuclear transport (SINE), can inhibit proliferation and promote apoptosis.