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Studies have reported conflicting results on the benefit of rituximab in combination with chemotherapy in patients with newly diagnosed primary central nervous system lymphoma (PCNSL). Here, we summarize the long-term results after a median follow-up of 82.3 months of phase III HOVON NHL 24 trial published by Bromberg et al.1 in Neuro-oncology investigating patients treated with methotrexate, BCNU (bis-chloroethylnitrosourea, carmustine), teniposide, and prednisolone (MBVP) with and without rituximab.
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