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How do we select a patient with R/R DLBCL for CAR-T?

During the European School of Haematology (ESH) How I manage CAR-T Therapies and Bispecific Antibodies for my Patients conference, the Lymphoma Hub spoke to Catherine Thieblemont, Hôpital Saint-Louis, Paris, FR. We asked, How do we select a patient with relapsed/refractory diffuse large B-cell lymphoma for CAR-T cell therapy?

How do we select a patient with R/R DLBCL for CAR-T?

Thieblemont summarizes the three main criteria in patient selection. The first, she explains, involves evaluation of disease progression and evolution. For the second she highlights that age is not a barrier, as shown in the ZUMA-1 trial. Finally she explains the importance of evaluating organ function and comorbidities.

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