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During the 4th European CAR T-Cell Meeting, the Lymphoma Hub was pleased to speak with Julio Delgado, Hospital Clínic de Barcelona, Barcelona, ES. We asked, How might CAR T-cells change the treatment landscape for patients with chronic lymphocytic leukemia (CLL)?
How might CAR T-cells change the treatment landscape for patients with CLL?
Delgado begins by outlining the recent improvements in CLL treatment, including new drug approvals (such as BTK and BCL-2 inhibitors). On the other hand, there are also patients (e.g., those with high-risk cytogenetics or for whom other therapies have failed) who are being referred for CAR-T therapy. However, Delgado highlights that there are no CAR-T cell products approved in the EU, meaning patients need to be enrolled in trials. Finally, Delgado gives his recommendations on treatment choices for high-risk CLL.
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ASH 2019 | Practice-changing abstracts in lymphoma and CLL
The Lymphoma Hub has developed a downloadable resource, which provides an update on the practice-changing abstracts in lymphoma and CLL from ASH 2019 in preparation for ASH 2020.
Phase I–II clinical trial with CAR-NK cells against CD19-positive non-Hodgkin lymphoma or chronic lymphocytic leukemia
Results on the first 11 patients from an ongoing phase I–II clinical trial assessing the safety and efficacy of escalating doses of...
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