How might CAR T-cells change the treatment landscape for patients with CLL?

During the 4th European CAR T-Cell Meeting, the Lymphoma Hub was pleased to speak with Julio Delgado, Hospital Clínic de Barcelona, Barcelona, ES. We asked, How might CAR T-cells change the treatment landscape for patients with chronic lymphocytic leukemia (CLL)?

Delgado begins by outlining the recent improvements in CLL treatment, including new drug approvals (such as BTK and BCL-2 inhibitors). On the other hand, there are also patients (e.g., those with high-risk cytogenetics or for whom other therapies have failed) who are being referred for CAR-T therapy. However, Delgado highlights that there are no CAR-T cell products approved in the EU, meaning patients need to be enrolled in trials. Finally, Delgado gives his recommendations on treatment choices for high-risk CLL.