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How might CAR T-cells change the treatment landscape for patients with CLL?

During the 4th European CAR T-Cell Meeting, the Lymphoma Hub was pleased to speak with Julio Delgado, Hospital Clínic de Barcelona, Barcelona, ES. We asked, How might CAR T-cells change the treatment landscape for patients with chronic lymphocytic leukemia (CLL)?

How might CAR T-cells change the treatment landscape for patients with CLL?

Delgado begins by outlining the recent improvements in CLL treatment, including new drug approvals (such as BTK and BCL-2 inhibitors). On the other hand, there are also patients (e.g., those with high-risk cytogenetics or for whom other therapies have failed) who are being referred for CAR-T therapy. However, Delgado highlights that there are no CAR-T cell products approved in the EU, meaning patients need to be enrolled in trials. Finally, Delgado gives his recommendations on treatment choices for high-risk CLL.

 

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