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Long-term results from a phase Ib/II study of magrolimab plus rituximab in R/R iNHL
By Ella Dixon
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The 3-year results from a multicenter, phase Ib/II trial (NCT02953509), which investigated magrolimab combined with rituximab (M+R) in patients with relapsed/refractory indolent non-Hodgkin lymphoma (R/R iNHL), were published in Blood Advances by Mehta et al.1 A total of 46 patients with R/R B-cell NHL were enrolled in phase Ib and received a priming dose of 1 mg/kg magrolimab followed by magrolimab maintenance doses of 10, 20, 30, or 45 mg/kg. In phase II, based on the safety data from phase Ib, maintenance doses of 30 and 45 mg/kg magrolimab combined with 375 mg/m2 rituximab were explored. The primary endpoints included the incidence and severity of treatment-emergent adverse events (TEAEs) and objective response rate (ORR) of M+R combination.1 |
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At least one TEAE and treatment-related TEAE were reported in 100% and 95.7% of patients, respectively. Infusion-related reaction (60.9%), headache (52.2%), and fatigue (45.7%) were the most common any grade TEAEs. The combination of M+R was well tolerated long term, with no new TEAEs identified during the follow-up period and no treatment-related deaths. |
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The M+R combination was associated with an ORR of 52.2%, with 30.4% of patients achieving a complete response. Among the responders, the median time to response was 1.8 months and the median duration of response was 15.9 months, indicating durable clinical benefit. |
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Responses with M+R were comparable across patient subgroups regardless of progression of disease ≤24 months or prior lines of therapy, suggesting its applicability in heavily pre-treated populations. |
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Median progression-free survival was 7.4 months and the median overall survival was not reached. |
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The results highlight the potential of M+R in iNHL, particularly for patients with limited treatment options due to refractory disease. Future studies should consider investigating M+R with emerging immunotherapies, such as CAR T-cell therapy or bispecific T-cell engagers, to potentially improve patient outcomes without adding significant toxicity. |
- Mehta A, Popplewell L, Collins GP, et al. Magrolimab plus rituximab in relapsed/refractory indolent non-Hodgkin lymphoma: Phase 1/2 trial 3-year follow-up. Blood Adv. Online ahead of print. DOI: 10.1182/bloodadvances.2024013277
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