The lym Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the lym Hub cannot guarantee the accuracy of translated content. The lym and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The Lymphoma & CLL Hub is an independent medical education platform, sponsored by Beigene, Johnson & Johnson and Roche, and supported through educational grants from Bristol Myers Squibb, Incyte, Lilly, and Pfizer. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View lym content recommended for you
Results from the phase III, open label, HD21 trial (NCT02661503) evaluating efficacy and tolerability of positron emission tomography (PET)-guided brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, and dexamethasone (BrECADD) versus bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (eBEACOPP) in newly diagnosed, advanced-stage, classical Hodgkin lymphoma were published by Borchmann et al.1 in The Lancet. |
Key learnings: |
The 4-year progression-free survival rate was higher in the BrECADD arm compared with eBEACOPP arm (94.3% vs 90.9%; hazard ratio, 0.66; p = 0.035). |
Treatment with BrECADD also resulted in lower rates of ≥1 treatment-related morbidity event compared with eBEACOPP (42% vs 59%; relative risk, 0.72; p < 0.0001). |
Patients in the BrECADD arm had a higher 4-year event-free survival rate compared with those in the eBEACOPP arm (91.4% vs 88.2%). |
Overall survival rates were comparable between the BreCADD and eBEACOPP arms (98.6% and 98.2%, respectively). |
The findings from the study show that BrECADD is better tolerated and more effective than eBEACOPP in the treatment of advanced stage classical Hodgkin lymphoma, and could become a potential standard fist-line treatment option in this patient population. |
The utilization of PET-guided BrECADD therapy allows for personalized treatment intensity, potentially reducing over-treatment and the associated toxicities. |
References
Please indicate your level of agreement with the following statements:
The content was clear and easy to understand
The content addressed the learning objectives
The content was relevant to my practice
I will change my clinical practice as a result of this content