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PET-guided BrECADD for the treatment of advanced-stage cHL
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Results from the phase III, open label, HD21 trial (NCT02661503) evaluating efficacy and tolerability of positron emission tomography (PET)-guided brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, and dexamethasone (BrECADD) versus bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (eBEACOPP) in newly diagnosed, advanced-stage, classical Hodgkin lymphoma were published by Borchmann et al.1 in The Lancet. |
| Key learnings: |
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The 4-year progression-free survival rate was higher in the BrECADD arm compared with eBEACOPP arm (94.3% vs 90.9%; hazard ratio, 0.66; p = 0.035). |
| Treatment with BrECADD also resulted in lower rates of ≥1 treatment-related morbidity event compared with eBEACOPP (42% vs 59%; relative risk, 0.72; p < 0.0001). |
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Patients in the BrECADD arm had a higher 4-year event-free survival rate compared with those in the eBEACOPP arm (91.4% vs 88.2%). |
| Overall survival rates were comparable between the BreCADD and eBEACOPP arms (98.6% and 98.2%, respectively). |
| The findings from the study show that BrECADD is better tolerated and more effective than eBEACOPP in the treatment of advanced stage classical Hodgkin lymphoma, and could become a potential standard fist-line treatment option in this patient population. |
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The utilization of PET-guided BrECADD therapy allows for personalized treatment intensity, potentially reducing over-treatment and the associated toxicities. |
- Borchmann P, Ferdinandus J, Schneider G, et al. Assessing the efficacy and tolerability of PET-guided BrECADD versus eBEACOPP in advanced-stage, classical Hodgkin lymphoma (HD21): a randomised, multicentre, parallel, open-label, phase 3 trial. Lancet. 2024;404(10450):341-352. DOI: 10.1016/S0140-6736(24)01315-1
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