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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On May 18, 2020, positive interim results were announced from the multi-center, open-label, phase I study of TRPH-222 (NCT03682796). This trial investigated the efficacy and safety of the next-generation antibody-drug conjugate, TRPH-222, in heavily pre-treated patients with relapsed and/or refractory B-cell lymphoma (non-Hodgkin lymphoma; NHL). The primary aim was to determine the maximum tolerated dose of TRPH-222; the secondary aims were to assess the safety, anti-tumor activity, and the pharmacokinetics. 1, 2
Data from the trial demonstrated early signs of a potential therapeutic benefit in the dose-escalation stage. Of the 19 heavily pretreated patients with NHL, five patients achieved a complete response at doses of 0.6 – 4.2 mg/kg every 3 weeks. Tumor reductions were seen in patients with both indolent and aggressive disease. Patients with follicular, diffuse large cell, and mantle cell lymphoma maintained a durable response. TRPH-222 was well-tolerated with a benign safety profile. The trial is currently ongoing with dose level of 10 mg/kg every 3 weeks. 1, 2
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