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Positive interim results announced for TRPH-222 in patients with NHL

May 21, 2020

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On May 18, 2020, positive interim results were announced from the multi-center, open-label, phase I study of TRPH-222 (NCT03682796). This trial investigated the efficacy and safety of the next-generation antibody-drug conjugate, TRPH-222, in heavily pre-treated patients with relapsed and/or refractory B-cell lymphoma (non-Hodgkin lymphoma; NHL).  The primary aim was to determine the maximum tolerated dose of TRPH-222; the secondary aims were to assess the safety, anti-tumor activity, and the pharmacokinetics. 1, 2

Data from the trial demonstrated early signs of a potential therapeutic benefit in the dose-escalation stage. Of the 19 heavily pretreated patients with NHL, five patients achieved a complete response at doses of 0.6 – 4.2 mg/kg every 3 weeks. Tumor reductions were seen in patients with both indolent and aggressive disease. Patients with follicular, diffuse large cell, and mantle cell lymphoma maintained a durable response. TRPH-222 was well-tolerated with a benign safety profile. The trial is currently ongoing with dose level of 10 mg/kg every 3 weeks. 1, 2

  1. Pharma C. Triphase, Catalent announce interim TRPH-222 results in NHL. Published May 19, 2020. Accessed May 20, 2020.
  2. Garcia D. Interim results of phase I study confirms safety with early signs of efficacy for TRPH-222 in NHL - Onco'Zine Published May 18, 2020. Accessed May 20, 2020.

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