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Marie José KerstenAt this year’s European School of Haematology (ESH) ‘2nd How to Diagnose and Treat: Lymphoma’ conference, the Lymphoma Hub hosted a virtual Satellite Symposium on the management and treatment of patients with relapsed/refractory (R/R) lymphoma. Professor Marie José Kersten, Amsterdam UMC, Amsterdam, NL, discussed how she would manage a patient with R/R diffuse large B-cell lymphoma (DLBCL) following relapse to chimeric antigen receptor (CAR) T-cell therapy.
Satellite Symposium | Patient with R/R DLBCL— European perspective
Marie-José Kersten provides an overview of the pivotal clinical trials evaluating CAR T-cell treatments for DLBCL, and the most widely understood mechanisms of resistance to CD19-directed CAR T-cell therapy.
After outlining a number of novel CAR-T constructs, she proceeds to discuss non-CAR T-based therapies and relevant clinical trial opportunities for the patient. These include studies evaluating bispecific antibodies, including epcoritamab and blinatumomab, and the CDK9 inhibitor AZD4573.
Satellite Symposium | Patient with R/R DLBCL— European perspective
If you would like to download the slides from Marie José Kersten's presentation, click below.
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In your experience, what is the average vein-to-vein time when treating patients with DLBCL with a reimbursed CAR T-cell therapy (from apheresis to infusion)?