Satellite Symposium | Patient with R/R DLBCL—European perspective

At this year’s European School of Haematology (ESH) ‘2nd How to Diagnose and Treat: Lymphoma’ conference, the Lymphoma Hub hosted a virtual Satellite Symposium on the management and treatment of patients with relapsed/refractory (R/R) lymphoma. Professor Marie José Kersten, Amsterdam UMC, Amsterdam, NL, discussed how she would manage a patient with R/R diffuse large B-cell lymphoma (DLBCL) following relapse to chimeric antigen receptor (CAR) T-cell therapy.

Marie-José Kersten provides an overview of the pivotal clinical trials evaluating CAR T-cell treatments for DLBCL, and the most widely understood mechanisms of resistance to CD19-directed CAR T-cell therapy.

After outlining a number of novel CAR-T constructs, she proceeds to discuss non-CAR T-based therapies and relevant clinical trial opportunities for the patient. These include studies evaluating bispecific antibodies, including epcoritamab and blinatumomab, and the CDK9 inhibitor AZD4573.